Base informative de référence, en France, sur la spiruline et l'univers des microalgues.
Les études scientifiques relatives à la spiruline
Si les chercheurs s'intéressent de plus en plus aux algues et microalgues, la spiruline est la plus étudiée d'entre elles avec près de 3000 publications scientifiques répertoriées sur Pubmed. Avant de lister les études les plus significatives, quelques mots sur l'origine de l'intérêt croissant pour l'algue bleue.
La genèse de l'intérêt scientifique pour la spiruline
Vers la fin des années 1820, elle est isolée par P.J. Turpin pour la toute première fois au départ d'un échantillon d'eau douce puis, moins de vingt ans plus tard, elle est décrite de manière détaillée à Montevideo (Uruguay).
Mais ce n'est qu'un feu de paille et cette découverte retombe vite au fin fond des oubliettes scientifiques. Du moins jusqu'à ce qu'elle soit une nouvelle fois identifiée sur les rives des lacs du Rift, en Afrique orientale. Elle est alors considérée comme l'un des composants essentiels du phytoplancton local, l'un des plus anciens et des mieux préservés de la planète.
Petit saut dans le temps... Au début de la Seconde Guerre mondiale, un scientifique français souligne pour la première fois l'utilisation alimentaire de la spiruline. Mais étant donné le contexte général de l'époque, son intervention passe complètement inaperçue. Le monde a d'autres préoccupations...
À la fin des années 1950 est publié le tout premier reportage qui a une réelle valeur scientifique et un certain retentissement. Signé par un ethnologue français et paru dans la revue « Sciences et Avenir », cet article souligne le fait qu'une peuplade des rives du lac Tchad utilise depuis longtemps une algue qui est appelée à devenir l'un des aliments du futur. Cette algue, contrairement à beaucoup d'autres qui ont tendance à s'enfoncer dans la vase, surnage, ce qui la rend facilement accessible et exploitable.
M.Y. Brandily partage sa découverte de la spiruline dans le magazine Science et Avenir d'octobre 1959.
C'est le début de l'aventure « scientifique » de la spiruline. À partir de ce moment, les recherches vont succéder aux études, confirmant quasiment tous les attraits nutritionnels et thérapeutiques de la microalgue. C'est aussi à partir de ce moment que des exploitants vont songer à la cultiver à plus ou moins grande échelle.
De nombreuses études scientifiques, dont des expériences in vitro & in vivo et des études randomisées en double aveugle ont montré des bénéfices santé grâce à la consommation de spiruline.
Résultats de recherche qui répondent au terme "spirulina" sur PubMed.
L'efficacité de la consommation de spiruline sur diverses pathologies a été expérimentalement démontré. Ces activités sont attribuées à la spiruline elle-même ou à certains de ses composants comme les acides gras omega-3 et omega-6, le bêta-carotène, la phycocyanine, le calcium Spirulan, etc.
Les publications scientifiques sur la spiruline :
Cette liste non exhaustive, permet à tout un chacun de consulter les écrits scientifiques qui évoquent la spiruline.
Elle sert également de base bibliographique pour la rédaction de ce site.
2024
- Moradi, Sajjad, et al. The effects of spirulina supplementation on serum iron and ferritin, anemia parameters, and fecal occult blood in adults with ulcerative colitis: A randomized, double-blinded, placebo-controlled trial. Clinical Nutrition ESPEN.
2023
- Tamtaji, Omid Reza, et al. The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double‐blind, controlled trial. Phytotherapy Research.
- Ali, Yunus, Rama Aubeeluck, and Tom Gurney. Fourteen-Days Spirulina Supplementation Increases Hemoglobin, but Does Not Provide Ergogenic Benefit in Recreationally Active Cyclists: A Double-Blinded Randomized Crossover Trial. Journal of Dietary Supplements.
- Shahinfar, Hossein, et al. Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: a systematic review and network meta-analysis of 111 randomized clinical trials. Pharmacological Research.
- Zhang, Yuting, et al. Effects on Spirulina Supplementation on Immune Cells’ Parameters of Elite College Athletes. Nutrients.
- van der Heijden, Ino, et al. Algae Ingestion Increases Resting and Exercised Myofibrillar Protein Synthesis Rates to a Similar Extent as Mycoprotein in Young Adults. The Journal of Nutrition.
2022
- Zhang, Yuting, et al. Effects on Spirulina Supplementation on Immune Cells’ Parameters of Elite College Athletes. Nutrients.
- Chaitanya, Nallan CSK, et al. Efficacy of Spirulina 500 mg vs Triamcinolone Acetonide 0.1% for the Treatment of Oral Lichen Planus: A Randomized Clinical Trial. The Journal of Contemporary Dental Practice.
- Choi, Woon-Yong, et al. The Effects of Spirulina maxima Extract on Memory Improvement in Those with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients.
- Bagheri, Reza, et al. Spirulina supplementation during gradual weight loss in competitive wrestlers. British Journal of Nutrition.
2021
- Zarezadeh, Meysam, et al. Spirulina supplementation and anthropometric indices: A systematic review and meta‐analysis of controlled clinical trials. Phytotherapy Research.
- Mazloomi, Seyed Mohammad et al. The effect of Spirulina sauce, as a functional food, on cardiometabolic risk factors, oxidative stress biomarkers, glycemic profile, and liver enzymes in nonalcoholic fatty liver disease patients: A randomized double-blinded clinical trial. Food science & nutrition.
- Moradi, Sajjad et al. The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative colitis: A randomised, double-blinded, placebo-controlled trial. International journal of clinical practice.
2019
- Carrizzo A, et al. Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent Mechanism. Hypertension.
- Louvel, S. La spiruline: intérêts humanitaires et thérapeutiques.
2018
- Kulshreshtha, Archana, et al. Spirulina in health care management. Current pharmaceutical biotechnology.
- Soudy ID, et al. Vitamin A status in healthy women eating traditionally prepared spirulina (Dihé) in the Chad Lake area. PLoS One.
- Park WS, et al. Two Classes of Pigments, Carotenoids and C-Phycocyanin, in Spirulina Powder and Their Antioxidant Activities. Molecules.
- Liu Q, et al. Medical Application of Spirulina platensis Derived C-Phycocyanin. Evid Based Complement Alternat Med.
- Huang H, et al. Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure. Diabetes Metab Syndr Obes.
- Brito AF, et al. Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and Antioxidants. Front Physiol.
- DiNicolantonio JJ, McCarty MF, O'Keefe JH. Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications. Open Heart.
2017
- Bowtell JL, et al. Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation. Appl Physiol Nutr Metab.
- Kerley CP. Dietary nitrate as a modulator of physical performance and cardiovascular health. Curr Opin Clin Nutr Metab Care.
- Neyrinck AM, et al. Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?. Nutrients.
- Szulinska M, et al. Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study. Eur Rev Med Pharmacol Sci.
- Roy-Lachapelle A, et al. Detection of Cyanotoxins in Algae Dietary Supplements. Toxins (Basel).
2016
- Whyte AR, Schafer G, Williams CM. Cognitive effects following acute wild blueberry supplementation in 7- to 10-year-old children. Eur J Nutr.
- Lu HK, et al. Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress. Eur J Appl Physiol.
- Martínez-Galero, Elizdath, et al. Preclinical antitoxic properties of Spirulina (Arthrospira). Pharmaceutical biology.
- Jensen GS, et al. Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation. J Med Food.
- Serban MC, et al. A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations. Clin Nutr.
- Miczke, A., et al. Effects of spirulina consumption on body weight, blood pressure, and endothelial function in overweight hypertensive Caucasians: a double-blind, placebo-controlled, randomized trial. Eur Rev Med Pharmacol Sci.
- Wu Q, et al. The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview. Arch Toxicol.
2015
- Hou LQ, Liu YH, Zhang YY. Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr.
- Braakhuis, Andrea J., and Will G. Hopkins. Impact of dietary antioxidants on sport performance: a review. Sports Medicine.
- Altenhöfer S, et al. Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxid Redox Signal.
- Chaiklahan R, et al. Separation and purification of phycocyanin from Spirulina sp. using a membrane process. Bioresour Technol.
2013
- Mazokopakis EE, et al. The hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: a prospective study. J Sci Food Agric.
- Ashraf R, et al. Effects of Allium sativum (Garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci.
- Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev.
- Kim DH, et al. Molecular Study of Dietary Heptadecane for the Anti-Inflammatory Modulation of NF-kB in the Aged Kidney. PLoS One.
- Siervo M, et al. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr.
- Siervo M, et al. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr.
- McCarty MF, Barroso-Aranda J, Contreras F. NADPH oxidase mediates glucolipotoxicity-induced beta cell dysfunction--clinical implications. Med Hypotheses.
- McCarty MF, Barroso-Aranda J, Contreras F. Clinical potential of Spirulina as a source of phycocyanobilin. J Med Food.
- Kulkarni RG, et al. Gilbert's syndrome in healthy blood donors what next??. Asian J Transfus Sci.
- Horsfall LJ, et al. Gilbert's syndrome and the risk of death: a population-based cohort study. J Gastroenterol Hepatol.
- Ou Y, et al. Antidiabetic potential of phycocyanin: Effects on KKAy mice. Pharm Biol.
- Ku CS, et al. Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes. Biochim Biophys Acta.
- Banji D, et al. Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride. Food Chem.
- Al-Dhabi NA. Heavy metal analysis in commercial Spirulina products for human consumption. Saudi J Biol Sci.
- Savranoglub S, Tumer TB. Inhibitory Effects of Spirulina platensis on Carcinogen-Activating Cytochrome P450 Isozymes and Potential for Drug Interactions. Int J Toxicol.
- Characterization of Spirulina Biomass for CELSS Diet Potential.
2012
- Rodríguez-Sánchez R, et al. Phycobiliproteins or C-phycocyanin of Arthrospira (Spirulina) maxima protect against HgCl(2)-caused oxidative stress and renal damage. Food Chem.
- Yakoot M, Salem A. Spirulina platensis versus silymarin in the treatment of chronic hepatitis C virus infection. A pilot randomized, comparative clinical trial. BMC Gastroenterol.
- Lim BJ, et al. C-phycocyanin attenuates cisplatin-induced nephrotoxicity in mice. Ren Fail.
- Teas J, Irhimeh MR. Dietary algae and HIV/AIDS: proof of concept clinical data. J Appl Phycol.
- Sinanoglu O, et al. The Protective Effects of Spirulina in Cyclophosphamide Induced Nephrotoxicity and Urotoxicity in Rats. Urology.
- Rendeiro C, et al. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology (Berl).
- Teas, Jane, et al. Algae–a poor man's HAART? Medical Hypotheses.
- Pugh N, et al. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Med.
- Watanabe F, et al. Characterization and bioavailability of vitamin B12-compounds from edible algae. J Nutr Sci Vitaminol (Tokyo).
- Saini MK, Sanyal SN. PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in rat. Exp Mol Pathol.
- Saini MK, Vaiphei K, Sanyal SN. Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin. Mol Cell Biochem.
- Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathway. Nutr Cancer.
- Gargouri M, et al. Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain and cerebellum of newborn rats. Food Chem Toxicol.
- Paniagua-Castro N, et al. Spirulina (Arthrospira) protects against cadmium-induced teratogenic damage in mice. J Med Food.
- Fujimoto M, et al. Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome. Dig Liver Dis.
- Pabon MM, et al. A Spirulina-Enhanced Diet Provides Neuroprotection in an α-Synuclein Model of Parkinson's Disease. PLoS One.
- Torres-Durán PV, et al. Effect of Spirulina maxima on postprandial lipemia in young runners: a preliminary report. J Med Food.
2011
- Moura LP, et al. Exercise and spirulina control non-alcoholic hepatic steatosis and lipid profile in diabetic Wistar rats. Lipids Health Dis.
- Selmi C, et al. The effects of Spirulina on anemia and immune function in senior citizens. Cell Mol Immunol.
- Ciferri O. Spirulina, the edible microorganism. Microbiol Rev.
- Kebede E, Ahlgren G. Optimum growth conditions and light utilization efficiency of Spirulina platensis (= Arthrospira fusiformis) (Cyanophyta) from Lake Chitu, Ethiopia. Hydrobiologia.
- Hwang JH, et al. Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated mice. J Nutr Sci Vitaminol (Tokyo).
- ALSUntangled Group. ALSUntangled No. 9: Blue-green algae (Spirulina) as a treatment for ALS. Amyotroph Lateral Scler.
- Patro N, et al. Spirulina platensis protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic rats. Indian J Exp Biol.
- Fang L, et al. Binding characteristics of copper and cadmium by cyanobacterium Spirulina platensis. J Hazard Mater.
- Yang Y, et al. In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis. Food Chem Toxicol.
- Marcel AK, et al. The effect of Spirulina platensis versus soybean on insulin resistance in HIV-infected patients: a randomized pilot study. Nutrients.
- Karkos, P. D., Leong, S. C., Karkos, C. D., Sivaji, N., & Assimakopoulos, D. A. Spirulina in clinical practice: evidence-based human applications. Evidence-based complementary and alternative medicine.
2010
- Potential health benefits of Spirulina microalgae.
- Sguera, S. Spirulina platensis et ses constituants: intérêts nutritionnels et activités thérapeutiques (Doctoral dissertation, UHP-Université Henri Poincaré).
- Acosta S, et al. NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat. Rejuvenation Res.
- Kalafati M, et al. Ergogenic and antioxidant effects of spirulina supplementation in humans. Med Sci Sports Exerc.
- McCarty MF, Barroso-Aranda J, Contreras F. Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders. Med Hypotheses.
- Saha SK, Misbahuddin M, Ahmed AU. Comparison between the effects of alcohol and hexane extract of spirulina in arsenic removal from isolated tissues. Mymensingh Med J.
- Petrus M, et al. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. Allergy.
- Nishanth RP, et al. C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line. Eur J Pharmacol.
- Thaakur S, Sravanthi R. Neuroprotective effect of Spirulina in cerebral ischemia-reperfusion injury in rats. J Neural Transm.
- Nielsen CH, et al. Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteins. Planta Med.
2009
- Ismail, Mohamed F., et al. Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina. International Journal of Biological Sciences.
- Ismail, Mohamed F., et al. Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina. International Journal of Biological Sciences.
- McCarty MF, Barroso-Aranda J, Contreras F. Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells. Med Hypotheses.
- Akao Y, et al. Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice. Cancer Sci.
- Juárez-Oropeza MA, et al. Effects of dietary Spirulina on vascular reactivity. J Med Food.
2008
- Yasuhara T, et al. Dietary supplementation exerts neuroprotective effects in ischemic stroke model. Rejuvenation Res.
- Habib MA, et al. A review on culture, production and use of spirulina as food for humans and feeds for domestic animals and fish. FAO Fisheries and Aquaculture Circular.
- Kulshreshtha, Archana, et al. Spirulina in health care management. Current pharmaceutical biotechnology.
- Gorban, E. M., et al. Clinical and experimental study of spirulina efficacy in chronic diffuse liver diseases. Likars' ka Sprava.
- Chu WL, et al. Protective effect of aqueous extract from Spirulina platensis against cell death induced by free radicals. BMC Complement Altern Med.
- Cain A, Vannela R, Woo LK. Cyanobacteria as a biosorbent for mercuric ion. Bioresour Technol.
- Solisio C, et al. Cadmium biosorption on Spirulina platensis biomass. Bioresour Technol.
- Kaur K, Sachdeva R, Grover K. Effect of supplementation of spirulina on blood glucose and lipid profile of the non-insulin dependent diabetic male subjects. Asian Journal of Dairy and Food Research.
- Lee EH, et al. A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Nutr Res Pract.
- Roy KR, et al. C-Phycocyanin ameliorates 2-acetylaminofluorene induced oxidative stress and MDR1 expression in the liver of albino mice. Hepatol Res.
- Bermejo-Bescós P, Piñero-Estrada E, Villar del Fresno AM. Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells. Toxicol In Vitro.
2007
- Shytle RD, et al. Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds. Rejuvenation Res.
- Liu Q, et al. Medical Application of Spirulina platensis Derived C-Phycocyanin. Evid Based Complement Alternat Med.
- McCarty MF. Clinical potential of Spirulina as a source of phycocyanobilin. J Med Food.
- Riss J, et al. Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters. J Agric Food Chem.
- Roy KR, et al. C-Phycocyanin inhibits 2-acetylaminofluorene-induced expression of MDR1 in mouse macrophage cells: ROS mediated pathway determined via combination of experimental and In silico analysis. Arch Biochem Biophys.
- Sharma MK, et al. Evaluation of protective efficacy of Spirulina fusiformis against mercury induced nephrotoxicity in Swiss albino mice. Food Chem Toxicol.
- McCarty MF. ''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Med Hypotheses.
- Akazawa T, et al. Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc Natl Acad Sci U S A.
- Thaakur SR, Jyothi B. Effect of spirulina maxima on the haloperidol induced tardive dyskinesia and oxidative stress in rats. J Neural Transm.
2006
- Bickford PC, et al. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cells Dev.
- Madhyastha HK, et al. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine.
- Ishimi Y, et al. Effects of spirulina, a blue-green alga, on bone metabolism in ovariectomized rats and hindlimb-unloaded mice. Biosci Biotechnol Biochem.
- Balachandran P, et al. Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice. Int Immunopharmacol.
- Grzanna R, et al. Immolina, a high-molecular-weight polysaccharide fraction of Spirulina, enhances chemokine expression in human monocytic THP-1 cells. J Altern Complement Med.
2005
- Wang Y, et al. Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Exp Neurol.
- Nagaoka S, et al. A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats. J Nutr.
- Itagaki T, et al. Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress-induced activation of cultured rat hepatic stellate cells. Gut.
- Mao TK, Van de Water J, Gershwin ME. Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients. J Med Food.
- Dietrich D, Hoeger S. Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): a reasonable or misguided approach?. Toxicol Appl Pharmacol.
2004
- Nemoto-Kawamura C, et al. Phycocyanin enhances secretary IgA antibody response and suppresses allergic IgE antibody response in mice immunized with antigen-entrapped biodegradable microparticles. J Nutr Sci Vitaminol (Tokyo).
2003
- Bataller R, et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest.
- Weisberg, Stuart P., et al. Obesity is associated with macrophage accumulation in adipose tissue. The Journal of clinical investigation.
2002
- Hirahashi T, et al. Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis. Int Immunopharmacol.
- Remirez D, et al. Inhibitory effects of Spirulina in zymosan-induced arthritis in mice. Mediators Inflamm.
- Gemma, Carmelina, et al. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar β-adrenergic function and increases in proinflammatory cytokines. Journal of Neuroscience.
- Liu XJ, et al. Effects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cells. World J Gastroenterol.
- Gemma C, et al. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. J Neurosci.
2001
- Dasgupta, Trisha, et al. Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and fore-stomach papillomagenesis by Spirulina platensis. Molecular and cellular biochemistry.
- Rodrıguez-Hernández, A., et al. Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes. Life Sciences.
- Parikh P, Mani U, Iyer U. Role of Spirulina in the Control of Glycemia and Lipidemia in Type 2 Diabetes Mellitus. J Med Food.
2000
- Reddy CM, et al. Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis. Biochem Biophys Res Commun.
1999
- Vigouroux C, et al. Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease. Diabetes Metab.
- Rimbau V, et al. Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus. Neurosci Lett.
- Torres-Durán, P. V., et al. Studies on the preventive effect of Spirulina maxima on fatty liver development induced by carbon tetrachloride, in the rat. Journal of Ethnopharmacology.
1998
- Kim, Hyung-Min, et al. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Spirulina. Biochemical Pharmacology.
- Ayehunie, Seyoum, et al. Inhibition of HIV-1 Replication by an Aqueous Extract of Spirulina platensis (Arthrospira platensis). JAIDS Journal of Acquired Immune Deficiency Syndromes.
- Jensen GS, et al. Supplementary effect of spirulina on hematological status of rats during pregnancy and lactation. Plant Foods for Human Nutrition.
- Salazar M, et al. Subchronic toxicity study in mice fed Spirulina maxima. J Ethnopharmacol.
- Kim, Hyung-Min, et al. Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Spirulina. Biochemical Pharmacology.
- Mishima T, et al. Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis. Clin Exp Metastasis.
1996
- Qureshi, M. A., and R. A. Ali. Spirulina platensis exposure enhances macrophage phagocytic function in cats. Immunopharmacology and immunotoxicology.
- Eyles DW, McGrath JJ, Pond SM. Formation of pyridinium species of haloperidol in human liver and brain. Psychopharmacology (Berl).
- Effect of Supplementation of Spirulina on Hypercholesterolemic Patients.
1995
- Mathew B, et al. Evaluation of chemoprevention of oral cancer with Spirulina fusiformis. Nutr Cancer.
1993
- Terry MJ, Maines MD, Lagarias JC. Inactivation of phytochrome- and phycobiliprotein-chromophore precursors by rat liver biliverdin reductase. J Biol Chem.
1990
- Subramanyam B, et al. Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats. Biochem Biophys Res Commun.
- Iwata, Kazuko, Takayo Inayama, and Toshimitsu Kato. Effects of Spirulina platensis on plasma lipoprotein lipase activity in fructose-induced hyperlipidemic rats. Journal of Nutritional Science and Vitaminology.
1989
- Qishen, Pang, Guo Baojiang, and Ada Kolman. Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studied by using the micronucleus test. Toxicology letters.
1983
- Ciferri O. Spirulina, the edible microorganism. Microbiol Rev.
1970
- Iwatsuka H, Shino A, Suzuoki Z. General survey of diabetic features of yellow KK mice. Endocrinol Jpn.
J'explore depuis près de 20 ans les publications de la littérature scientifique qui concernent la spiruline, ses composants et plus largement, les microalgues. Je m'efforce de fournir des articles sourcés et régulièrement vérifiés en fonction des nouvelles données de la recherche.
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